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The primary atrophic GM areas ( Figure 1 ) in the smokers with moderate nicotine dependence were the middle occipital gyrus (MOG), posterior cingulate (PC) cortex, cerebellum anterior lobe (CAL), precuneus, and caudate body (CB), although only some of these GM areas were found with significant atrophy in smokers with severe nicotine dependence ( Figure 1 )

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